Central to Watts and Newson’s argument in their seminal paper ‘ Is there a duty to routinely reinterpret genomic variant classifications? ’ is that diagnostic laboratories are not morally obligated to actively reinterpret variants of uncertain significance (VUS) due to the superior outcomes offered by next-generation sequencing (NGS) compared with traditional methods.1 NGS technologies can identify, analyse and interpret millions of genetic variations at once. For example, ‘the use of conventional molecular assays in clinical contexts could require doing a lot (...) of assays for various mutations. Using these different assays, more tissue may be required. These targets can accurately be questioned using NGS technology in a single test.’2 If NGS-based genomic sequencing is reliable and its output outweighs the potential harm of uncertainties, then, it is plausible to say that those test providers cannot incur a moral duty to actively reinterpret VUS because there won’t be any need to do so.1 Despite its seeming reliability, diagnostic laboratories face enormous challenges in implementing NGS-based …. (shrink)

Business Ethics for Future Leaders presents students with contemporary readings in the discipline that highlight the changing dynamics of ethics in today's business world and challenge readers to transcend the traditional leadership mindset. In Section I, students read articles that address how ethical behavior can contribute to organizational success, why individuals view ethical behavior differently, and how leaders can incorporate ethical principles into their decision making. Section II focuses on ethical challenges in the multigenerational workplace. In Sections III and IV, (...) students learn about the ideal mindset for ethical leaders and ethical challenges related to cyber security and the internet. Additional sections discuss the ethics of business decision making, sustainable environmental management, and ethical climate and safety performance. The final section speaks to ethical public affairs, issues, and crisis management. Featuring highly accessible readings, Business Ethics for Future Leaders is an ideal supplemental textbook for courses in business and leadership. (shrink)

The aim of this paper is to define a partial Propositional Type Theory. Our system is partial in a double sense: the hierarchy of (propositional) types contains partial functions and some expressions of the language, including formulas, may be undefined. The specific interpretation we give to the undefined value is that of Kleene’s strong logic of indeterminacy. We present a semantics for the new system and prove that every element of any domain of the hierarchy has a name in the (...) object language. Finally, we provide a proof system and a (constructive) proof of completeness. (shrink)

This new Encyclopedia of Postmodernism is structured with biographical entries on all the key contributors to the postmodernism debate, including Mikhail Bakhtin, Pierre Bourdieum, Jacques Derrida, Jurgen Habermas and Wittgenstein. Providing an all-encompassing and welcome addition to the field, the Encyclopedia contains entries on foundational concepts of postmodernism which have revolutionized thinking in every intellectual discipline. This new Encyclopedia is the first to provide comprehensive A-Z coverage of the key individuals and concepts of postmodernism. The 300+ entries include: * African (...) American studies * Roland Barthes * binary opposition * Buddhism * comparative literature * cyberculture * death of God * Gilles Deleuze * desire * digital culture * end of history * globalization * grand narrative * improvisation * jouissance * logocentrism * metalanguage * sadism * theatre arts * trope * visuality * Cornell West * and much more. Fully cross-referenced and indexed, with suggestionsfor further reading. (shrink)

Despite extensive research and a multitude of computer systems, there is no viable computerized system that is even remotely capable of approaching the skill of an expert human physician. Minor obstacles in the design of a practical system include imprecise medical terminology, the use of nonindependent clinical parameters, incorrect or inaccurate information supplied to the computer, and static representation of a patient's medical history. Major problems that go beyond computer manipulation of data include the requirement for a massive data base, (...) representation of medical knowledge in general rather than specific terms, and physician fallibility in the design of a computer system. CiteULike Connotea Del.icio.us What's this? (shrink)

This book examines leadership strategies that allow administrators to be proactive, visionary, and flexible while increasing collaboration, open communication, and closely integrating theory and practice to ensure successful administration in higher education settings.

Routledge is now re-issuing this prestigious series of 204 volumes originally published between 1910 and 1965. The titles include works by key figures such asC.G. Jung, Sigmund Freud, Jean Piaget, Otto Rank, James Hillman, Erich Fromm, Karen Horney and Susan Isaacs. Each volume is available on its own, as part of a themed mini-set, or as part of a specially-priced 204-volume set. A brochure listing each title in the "International Library of Psychology" series is available upon request.

Brazilian society has frequently been described as polarized during the country’s recent political and economic crisis. In 2018, a wave of opposition to the centre-left Workers’ Party culminated in the election of Jair Bolsonaro, a right-wing populist who portrays the political left as a malevolent force in Brazilian society. In this paper I explore this polarization through drawing on ethnographic research with the Homeless Workers’ Movement (Movimento de Trablhadores Sem-Teto, MTST), a large urban social movement that develops settlements on underutilized (...) land in the city, and a prominent civil society opponent of Bolsonaro. More specifically, I examine a key site of socio-spatial tension in São Paulo, Paulista Avenue, as a new political right came to predominate on the city’s main thoroughfare during the campaign to impeach the Workers’ Party President, Dilma Rousseff. I show how the perceived intolerance of the mobilized right helped to establish new normative codes that regulated the political symbolism which could be displayed in public spaces. Lastly, I consider how the vilification of the MTST in particular and the political left in general by the new right is embedded in broader structures of stigmatization. (shrink)

Vigorous Fodorian criticism may make it seem impossible for Inferential Role Semantics (IRS) to accommodate compositionality. In this paper, first, I introduce a neo-Fregean version of IRS that appeals centrally to the notion of rationality. Second, I show how such a theory can respect compositionality by means of semantic rules. Third, I argue that, even if we consider top-down compositional derivability: a) the Fodorian is not justified in claiming that it involves so-called reverse compositionality; and b) a defender of IRS (...) can still offer a satisfactory account in terms of the inferential capacities of rational thinkers. (shrink)

Since 1923 the Sammlung Tusculum has published authoritative editions of Greek and Latin works together with a German translation. The original texts are comprehensively annotated, and feature an introductory chapter. In the new volumes, additional essays delve into specific aspects of the works, illuminating their historical context and reception to the present day. The high academic quality of the new editions together with clearly written essays and annotations make the Sammlung Tusculum essential reading for students who are discovering an ancient (...) author for the first time as well as professional scholars who would like to gain a deeper understanding of specific aspects of a given work. Moreover, the series is ideal for lay readers who would like to engage with antiquity through a reliable German translation. The series contains over 270 titles, available in print and eBook editions, making previously out-of-print titles and rarities available again for the first time. In order to celebrate the 90th anniversary of the series, De Gruyter is proud to present Tusculum Online, an eBook package which contains all titles that appeared between 1923 and 2013 - a fitting tribute to an important part of German publishing history. For more information, please see www.degruyter.com/tusculum. (shrink)